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Answer: No. It is impossible to infect all 10,000 cells.
Defines $P$ as the number of edges between infected and non-infected squares (including the outer edge of the board).
When a healthy square becomes infected, it had $k\ge2$ infected orthogonal neighbors.
- $k$ border edges are removed,
- new $4-k$ borders are added.
Then the net change is:
$$
\Delta P=(4-k)-k=4-2k\le0.
$$
So $P$ never increases.
At the beginning, with 99 infected squares:
$$
P_0\le 99\cdot4=396.
$$
If the entire $100\times100$ board were infected, the outer border would be:
$$
P_f=4\cdot100=400.
$$
But that would require growing from $\le396$ to 400, a contradiction.
Conclusion: total infection cannot occur.